Twelfth College was opened in May 2000. Initially, the accommodation was open to only female students. Couples of years later, the college started to welcome male students. The maintenance of facilities at the Twelfth College is under the supervision of a private company, PJS Development Pvt Ltd (PJSD). The management of college activities is under the responsibility of the Twelfth College and Universiti Putra Malaysia. At the end of 2006, the restructuring of Twelfth College was implemented where the Block and Wing division took effect.