The Twelfth College was opened in May 2000. Initially, the accommodation was open to only female students. Couple of years later, the college started to welcome male students. The maintenance of facilities at the Twelfth College is under the supervision of a private company, PJSD Berhad.
The management of college activities are under responsibility of The Twelfth College and Universiti Putra Malaysia. At the end 2006, The Twelfth College restructuring was implemented where the Block and Wing division took effect.